Molecular imaging of angiogenesis in nascent Vx-2 rabbit tumors using a novel alpha(nu)beta3-targeted nanoparticle and 1.5 tesla magnetic resonance imaging

• Published in: Cancer research (Chicago, Ill.) Vol. 63; no. 18; pp. 5838 - 5843
• Main Authors: Winter, Patrick M, Caruthers, Shelton D, Kassner, Andrea, Harris, Thomas D, Chinen, Lori K, Allen, John S, Lacy, Elizabeth K, Zhang, Huiying, Robertson, J David, Wickline, Samuel A, Lanza, Gregory M
• Format: Journal Article
• Language: English
• Published: United States 15.09.2003
• Subjects: Animals; Hindlimb; Integrin alphaVbeta3 - biosynthesis; Integrin alphaVbeta3 - metabolism; Magnetic Resonance Angiography - methods; Male; Nanotechnology; Neoplasm Transplantation; Neoplasms, Experimental - blood supply; Neovascularization, Pathologic - diagnosis; Neovascularization, Pathologic - metabolism; Particle Size; Rabbits

Early noninvasive detection and characterization of solid tumors and their supporting neovasculature is a fundamental prerequisite for effective therapeutic intervention, particularly antiangiogenic treatment regimens. Emerging molecular imaging techniques now allow recognition of early biochemical,...