alpha vbeta 6 Integrin promotes the invasion of morphoeic basal cell carcinoma through stromal modulation

• Published in: Cancer research (Chicago, Ill.) Vol. 68; no. 9; pp. 3295 - 3303
• Main Authors: Marsh, Daniel, Dickinson, Sarah, Neill, Graham W, Marshall, John F, Hart, Ian R, Thomas, Gareth J
• Format: Journal Article
• Language: English
• Published: United States 01.05.2008
• Subjects: Animals; Antibodies - pharmacology; Antigens, Neoplasm - metabolism; Antigens, Neoplasm - physiology; Carcinoma, Basal Cell - metabolism; Carcinoma, Basal Cell - pathology; Cell Movement - genetics; Cells, Cultured; Hepatocyte Growth Factor - metabolism; Humans; Integrins - antagonists & inhibitors; Integrins - metabolism; Integrins - physiology; Keratinocytes - metabolism; Kruppel-Like Transcription Factors - genetics; Kruppel-Like Transcription Factors - metabolism; Mink; Neoplasm Invasiveness; Nuclear Proteins - genetics; Nuclear Proteins - metabolism; Proto-Oncogene Proteins c-met - metabolism; RNA, Small Interfering - pharmacology; Skin Neoplasms - metabolism; Skin Neoplasms - pathology; Stromal Cells - metabolism; Stromal Cells - pathology; Transcription Factors - genetics; Transcription Factors - metabolism; Transforming Growth Factor beta1 - metabolism; Zinc Finger Protein GLI1; Zinc Finger Protein Gli2

Basal cell carcinoma (BCC) is the most prevalent cancer in the Western world and its incidence is increasing. The pathogenesis of BCC involves deregulated Sonic hedgehog signaling, leading to activation of the Gli transcription factors. Most BCCs have a nodular growth pattern, and are indolent, slow...