Spontaneous transformation and immortalization of mesenchymal stem cells in vitro

• Published in: T͡S︡itologii͡a Vol. 51; no. 2; p. 91
• Main Authors: Popov, B V, Petrov, N S, Mikhaĭlov, V M, Tomilin, A N, Alekseenko, L L, Grinchuk, T M, Zaĭchik, A M
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2009
• Subjects: Animals; Cell Transformation, Neoplastic - metabolism; Cell Transformation, Neoplastic - pathology; Cells, Cultured; Green Fluorescent Proteins - metabolism; Humans; Karyotyping; Male; Mesenchymal Stromal Cells - metabolism; Mesenchymal Stromal Cells - pathology; Mice; Mice, Inbred C57BL; Mice, Transgenic

Mesenchymal stem cells (MXC) possess plasticity and unlimited proliferative activity in vitro that makes them an attractive subject of the studies focused on searching new resources for regenerative medicine. The usage of MSC is effective for treatment of patients with degenerative and traumatic dis...