TNFalpha promotes osteogenic differentiation of human mesenchymal stem cells by triggering the NF-kappaB signaling pathway

• Published in: Bone (New York, N.Y.) Vol. 45; no. 2; p. 367
• Main Authors: Hess, Katrin, Ushmorov, Alexey, Fiedler, Jörg, Brenner, Rolf E, Wirth, Thomas
• Format: Journal Article
• Language: English
• Published: United States 01.08.2009
• Subjects: Alkaline Phosphatase - metabolism; Alleles; Bone Morphogenetic Protein 2 - metabolism; Calcification, Physiologic - drug effects; Cell Differentiation - drug effects; Extracellular Matrix - drug effects; Extracellular Matrix - metabolism; Humans; I-kappa B Kinase - metabolism; Mesenchymal Stromal Cells - cytology; Mesenchymal Stromal Cells - enzymology; Mesenchymal Stromal Cells - metabolism; Mesenchymal Stromal Cells - virology; NF-kappa B - metabolism; Osteogenesis - drug effects; Retroviridae; Signal Transduction - drug effects; Tumor Necrosis Factor-alpha - pharmacology

Mesenchymal stem cells are multipotent cells able to differentiate into different mesenchymal lineages. Studies in the past had suggested that two of these mesenchymal differentiation directions, the chondrogenic and the myogenic differentiation, are negatively regulated by the transcription factor...