Effect of thymopentin on production of cytokines, heat shock proteins, and NF-kappaB signaling proteins

In vivo effects of thymopentin, an active fragment of the naturally occurring thymic hormone thymopoietin, on the production of cytokines, nitric oxide, heat shock proteins, and signal proteins NF-kappaB, phNF-kappaB, and IkappaB-alpha in lymphoid cells of male NMRI mice was studied. Activation of p...

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Published inIzvestiia Akademii nauk. Seriia biologicheskaia no. 4; p. 422
Main Authors Novoselova, E G, Lunin, S M, Khrenov, M O, Cherenkov, D A, Novoselova, T V, Lysenko, E A, Fesenko, E E
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.07.2008
Subjects
Animals
Cells, Cultured
Cytokines - biosynthesis
Heat-Shock Proteins - biosynthesis
Lymphocytes - drug effects
Lymphocytes - physiology
Macrophages, Peritoneal - drug effects
Macrophages, Peritoneal - physiology
Male
Mice
NF-kappa B
Nitric Oxide - biosynthesis
Phosphorylation - drug effects
Thymopentin - pharmacology
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Summary:In vivo effects of thymopentin, an active fragment of the naturally occurring thymic hormone thymopoietin, on the production of cytokines, nitric oxide, heat shock proteins, and signal proteins NF-kappaB, phNF-kappaB, and IkappaB-alpha in lymphoid cells of male NMRI mice was studied. Activation of production of several cytokines (IL-1alpha, IL-2, IL-6, IL-10, and IFN-gamma), nitric oxide, and heat shock proteins (HSP70 and HSP90) was observed in peritoneal macrophages and spleen lymphocytes of mice that received intraperitoneal injections of thymopentin (15 microg per 100 g body weight). Thymopentin apparently produces stress-like rather than damaging effects. A probable action mechanism of this hormone is activation of the NF-kappaB signaling pathway, which is most pronounced at the NF-kappaA phosphorylation stage.
ISSN:1026-3470