Herpes simplex virus 2 modulates apoptosis and stimulates NF-kappaB nuclear translocation during infection in human epithelial HEp-2 cells

• Published in: Virology (New York, N.Y.) Vol. 342; no. 2; pp. 297 - 310
• Main Authors: Yedowitz, Jamie C, Blaho, John A
• Format: Journal Article
• Language: English
• Published: United States 25.11.2005
• Subjects: Active Transport, Cell Nucleus; Apoptosis; Cell Nucleus - metabolism; Cycloheximide - pharmacology; Epithelial Cells - metabolism; Epithelial Cells - physiology; Epithelial Cells - virology; Herpes Simplex - virology; Herpesvirus 2, Human - physiology; Humans; NF-kappa B - metabolism; Protein Synthesis Inhibitors - pharmacology; Time Factors

Virus-mediated apoptosis is well documented in various systems, including herpes simplex virus 1 (HSV-1). HSV-2 is closely related to HSV-1 but its apoptotic potential during infection has not been extensively scrutinized. We report that (i) HEp-2 cells infected with HSV-2(G) triggered apoptosis, as...