Treatment with nebulized lidocaine in steroid-dependent asthma

• Published in: Allergologia et immunopathologia Vol. 33; no. 4; p. 231
• Main Authors: de Paz Arranz, S, Rodríguez Mosquera, M, Fernández Parra, B, Santaolalla Montoya, M, Herrera Mozo, I, Pérez Pimiento, A
• Format: Journal Article
• Language: Spanish
• Published: Spain 01.07.2005
• Subjects: Administration, Inhalation; Administration, Oral; Adrenal Cortex Hormones - administration & dosage; Adrenal Cortex Hormones - adverse effects; Adrenal Cortex Hormones - therapeutic use; Adrenergic beta-Antagonists - administration & dosage; Adrenergic beta-Antagonists - therapeutic use; Aerosols; Asthma - drug therapy; Eosinophilia - drug therapy; Eosinophilia - etiology; Eosinophils - drug effects; Female; Humans; Lidocaine - administration & dosage; Lidocaine - pharmacology; Lidocaine - therapeutic use; Methylprednisolone - administration & dosage; Methylprednisolone - adverse effects; Methylprednisolone - therapeutic use; Middle Aged; Nebulizers and Vaporizers; Prednisone - administration & dosage; Prednisone - adverse effects; Prednisone - therapeutic use; Pregnenediones - administration & dosage; Pregnenediones - adverse effects; Pregnenediones - therapeutic use; Remission Induction; Substance-Related Disorders
• ISSN: 0301-0546

The management of glucocorticoid dependent and resistant asthma encompasses a group of problems, affecting as much control of clinical symptoms as the onset of adverse effects to prolonged use of steroids. Woman 52 years old, steroid dependent asthma fifteen years ago. She has important adverse effects in consequence of the use of systemic glucocorticoids. The employment of methotrexate attained decrease in the dosage of steroids temporarily. The worsening of the clinical situation and deterioration of secondary effects by use of steroids necessitated treatment with nebulized lidocaine. A 2% solution to initial dosage was administered three times daily. The maximal dosage needed was 80 mg three times daily. After three months of lidocaine treatment, the patient was able to reduce oral steroids eventually discontinuing these drugs, and the effects secondary to exogenous hypercortisolism disappeared. Moreover, an improvement in clinical symptoms and quality of life was observed with stability in the pulmonary function. The use of nebulized lidocaine could be useful and provide alternatives in patients with severe asthma.