Tuberculosis-induced variant IL-4 mRNA encodes a cytokine functioning as growth factor for (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate-specific Vgamma2Vdelta2 T cells

• Published in: The Journal of immunology (1950) Vol. 182; no. 2; pp. 811 - 819
• Main Authors: Yuan, ZhuQing, Wang, Richard, Lee, Yuyang, Chen, Crystal Y, Yu, XingBing, Wu, ZhongDao, Huang, Dan, Shen, Ling, Chen, Zheng W
• Format: Journal Article
• Language: English
• Published: United States 15.01.2009
• Subjects: Amino Acid Sequence; Animals; Base Sequence; Cell Proliferation; Diphosphates - immunology; Intercellular Signaling Peptides and Proteins - biosynthesis; Intercellular Signaling Peptides and Proteins - genetics; Intercellular Signaling Peptides and Proteins - physiology; Interleukin-4 - biosynthesis; Interleukin-4 - genetics; Interleukin-4 - isolation & purification; Interleukin-4 - physiology; Lymphocyte Activation - immunology; Macaca fascicularis; Macaca mulatta; Molecular Sequence Data; Mycobacterium bovis - immunology; Mycobacterium tuberculosis - immunology; Receptors, Antigen, T-Cell, gamma-delta - immunology; RNA Splicing - immunology; RNA, Messenger - biosynthesis; T-Lymphocyte Subsets - immunology; T-Lymphocyte Subsets - metabolism; T-Lymphocyte Subsets - microbiology

The possibility that mycobacterial infections induce variant cytokine mRNA encoding a functionally distinct protein for immune regulation has not been addressed. In this study, we reported that Mycobacterium tuberculosis and bacillus Calmette-Guérin infections of macaques induced expression of varia...