Nitric oxide (NO) induces nitration of protein kinase Cepsilon (PKCepsilon ), facilitating PKCepsilon translocation via enhanced PKCepsilon -RACK2 interactions: a novel mechanism of no-triggered activation of PKCepsilon

• Published in: The Journal of biological chemistry Vol. 277; no. 17; pp. 15021 - 15027
• Main Authors: Balafanova, Zarema, Bolli, Roberto, Zhang, Jun, Zheng, Yuting, Pass, Jason M, Bhatnagar, Aruni, Tang, Xian-Liang, Wang, Ouli, Cardwell, Ernest, Ping, Peipei
• Format: Journal Article
• Language: English
• Published: United States 26.04.2002
• Subjects: Amino Acid Sequence; Animals; Enzyme Activation; Isoenzymes - metabolism; Molecular Sequence Data; Nitrates - metabolism; Nitric Oxide - physiology; Nitric Oxide Donors - pharmacology; Phosphorylation; Protein Kinase C - metabolism; Protein Kinase C-epsilon; Protein Transport; Rabbits; S-Nitroso-N-Acetylpenicillamine - pharmacology

Activation of protein kinase C (PKC) epsilon by nitric oxide (NO) has been implicated in the development of cardioprotection. However, the cellular mechanisms underlying the activation of PKCepsilon by NO remain largely unknown. Nitration of protein tyrosine residues has been shown to alter function...