alpha1 Integrin activation: a link between beta-amyloid deposition and neuronal death in aging hippocampal neurons

• Published in: Journal of neuroscience research Vol. 75; no. 5; p. 688
• Main Authors: Anderson, Kelsi L, Ferreira, Adriana
• Format: Journal Article
• Language: English
• Published: United States 01.03.2004
• Subjects: Aging - metabolism; Aging - pathology; Amyloid beta-Peptides - metabolism; Animals; Cell Death - physiology; Enzyme Inhibitors - pharmacology; Hippocampus - metabolism; Hippocampus - pathology; Integrin alpha1 - drug effects; Integrin alpha1 - metabolism; Integrin alpha1beta1 - drug effects; Integrin alpha1beta1 - metabolism; Mitogen-Activated Protein Kinases - drug effects; Mitogen-Activated Protein Kinases - metabolism; Neurofibrils - metabolism; Neurons - metabolism; Neurons - pathology; Peptides - pharmacology; Rats; Signal Transduction - drug effects

A growing body of evidence obtained using in vitro model systems indicates that the deposition of fibrillar beta-amyloid (Abeta) results in neurite degeneration and cell death in central neurons. Little is known, however, about the molecular mechanisms underlying these neurotoxic effects. We have sh...