Efficacy of ciprofloxacine antibiotic prophylaxis of infectious complications after TUR of the prostate

We compared efficacy of preoperative prophylactic antibiotic treatment (PPAT) with cyprofloxacine used orally (0.5 g), intravenously (0.4 g) and routine antibiotics in TUR of the prostate. A multicenter open randomized study covered 120 patients. PPAT efficacy was estimated by the rate of urinary in...

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Published inUrologii͡a︡ (Moscow, Russia : 1999) no. 5; p. 21
Main Authors Rafal'skiĭ, V V, Strachunskiĭ, L S, Kogan, M I, Petrov, S B, Grinev, A V, Veliev, E I, Kopylov, V V, Iskorostinskiĭ, E V, Kirekhin, I V
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.09.2005
Subjects
Administration, Oral
Aged
Anti-Infective Agents - administration & dosage
Anti-Infective Agents - therapeutic use
Antibiotic Prophylaxis
Ciprofloxacin - administration & dosage
Ciprofloxacin - therapeutic use
Humans
Injections, Intravenous
Male
Middle Aged
Postoperative Complications - prevention & control
Prostate - surgery
Prostatic Hyperplasia - surgery
Transurethral Resection of Prostate
Urinary Tract Infections - prevention & control
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Summary:We compared efficacy of preoperative prophylactic antibiotic treatment (PPAT) with cyprofloxacine used orally (0.5 g), intravenously (0.4 g) and routine antibiotics in TUR of the prostate. A multicenter open randomized study covered 120 patients. PPAT efficacy was estimated by the rate of urinary infection (UI), frequency and duration of antibiotic treatment in the postoperative period, hospitalization duration. All the patients were divided into three groups: 39 patients of group 1 received oral cyprofloxacine 90-120 min before TUR of the prostate, 38 patients of group 2 received intravenous cyprofloxacine 30-60 min before TUR, 43 patients of group 3 (control) received routine antibiotic prophylaxis. The following results were obtained: 24-48 hours after the operation no cases of UI in group 1, 11.5 and 11.6% in groups 2 and 3, respectively, (p = 0.048); 7 days after TUR--UI in all the groups (2.6, 20, 23.3%, respectively); 14 days after TUR--UI in 5.1, 28.6, 27.9% patients, respectively. Mean duration of hospital stay was 11.7 +/- 7.6 days in group 1, 12.1 +/- 8.1 days in group 2, 12.5 +/- 7.8 days in group C (p > 0.05). Postoperative antibiotics were given to 16.7, 34.1 and 68.9% patients, respectively. Thus, cyprofloxacine in group 1 lowered UI risk and postoperative antibiotics significantly, in group 2 it had no influence on UI rate but reduced postoperative antibiotics significantly.
ISSN:1728-2985