Analysis of the CC chemokine receptor 5Delta32 polymorphism in pediatric liver transplant recipients

• Published in: Pediatric transplantation Vol. 12; no. 7; p. 769
• Main Authors: Fischer-Maas, Louise, Schneppenheim, Reinhard, Oyen, Florian, Grabhorn, Enke, Richter, Andrea, Fischer, Lutz, Ganschow, Rainer
• Format: Journal Article
• Language: English
• Published: Denmark 01.11.2008
• Subjects: Adolescent; Biliary Atresia - therapy; Child; Child, Preschool; Cohort Studies; Female; Humans; Immunosuppressive Agents - therapeutic use; Infant; Liver Diseases - genetics; Liver Diseases - therapy; Liver Transplantation - methods; Male; Polymorphism, Genetic; Primary Graft Dysfunction - etiology; Primary Graft Dysfunction - genetics; Receptors, CCR5 - genetics; Receptors, CCR5 - metabolism

In adult liver graft recipients, it has been shown that certain chemokine polymorphisms (CCR5Delta32) may correspond to ischemic type biliary lesions leading to chronic graft dysfunction. The aim of our present study was to assess the importance of CCR5Delta32 polymorphism in a cohort of pediatric l...