P-glycoprotein expression in radiation-associated acute myeloid leukemia

The article presents findings of the analysis on P-glycoprotein expression of leukemic cells in 52 acute myeloid leukemia (AML) patients. Of these, there were 20 persons exposed to ionizing radiation due to the Chernobyl accident and 32 patients with spontaneous disease. Leukemic cells in patients w...

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Bibliographic Details
Published inLikars'ka sprava no. 3; p. 29
Main Authors Bebeshko, V H, Bazyka, D A, Klymenko, S V, Maznichenko, O L, Holiarnik, N A, Liaskovs'ka, O V, Il'ienko, I M, Tretiak, N M, Vdovtsov, O O, Serbinenko, T M, Zubryts'ka, T B, Zinchenko, V N
Format Journal Article
LanguageUkrainian
Published Ukraine 01.04.2005
Subjects
Acute Disease
Adult
Aged
Aged, 80 and over
ATP-Binding Cassette, Sub-Family B, Member 1 - biosynthesis
Bone Marrow Cells - metabolism
Chernobyl Nuclear Accident
Female
Flow Cytometry
Fluorescent Antibody Technique, Indirect
Humans
Leukemia, Myeloid - blood
Leukemia, Myeloid - metabolism
Leukemia, Myeloid - mortality
Leukemia, Radiation-Induced - blood
Leukemia, Radiation-Induced - metabolism
Leukemia, Radiation-Induced - mortality
Leukocytes - metabolism
Male
Middle Aged
Survival Analysis
Ukraine
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Summary:The article presents findings of the analysis on P-glycoprotein expression of leukemic cells in 52 acute myeloid leukemia (AML) patients. Of these, there were 20 persons exposed to ionizing radiation due to the Chernobyl accident and 32 patients with spontaneous disease. Leukemic cells in patients with radiation-associated AML compared to spontaneous cases more often were P-glycoprotein positive (12/20 vs 9/32, P<0,05). P-glycoprotein overexpression significantly correlated with resistant disease in patients with radiation-associated AML, but was not a prognostic variable for treatment outcome in terms of overall survival.
ISSN:1019-5297