Critical review and evaluation of the uterotrophic bioassay for the identification of possible estrogen agonists and antagonists: in support of the validation of the OECD uterotrophic protocols for the laboratory rodent. Organisation for Economic Co-operation and Development

• Published in: Critical reviews in toxicology Vol. 32; no. 6; p. 445
• Main Authors: Owens, J William, Ashby, John
• Format: Journal Article
• Language: English
• Published: England 2002
• Subjects: Animals; Biological Assay - standards; Estradiol - toxicity; Estrogen Antagonists - toxicity; Ethinyl Estradiol - toxicity; Female; Mice; Organ Size; Program Evaluation; Rats; Receptors, Estrogen - agonists; Receptors, Estrogen - antagonists & inhibitors; Uterus - drug effects; Uterus - metabolism; Uterus - pathology

A current issue for regulatory agencies is endocrine-related modes of action such as those mediated by the estrogen, androgen, and thyroid nuclear receptors. At the national and international levels, the consensus recommendation for the assessment of such modes of action is a tiered series of in vit...