The inhibition of Wnt/beta-catenin signalling by 1alpha,25-dihydroxyvitamin D3 is abrogated by Snail1 in human colon cancer cells

• Published in: Endocrine-related cancer Vol. 14; no. 1; pp. 141 - 151
• Main Authors: Larriba, María Jesús, Valle, Noelia, Pálmer, Héctor G, Ordóñez-Morán, Paloma, Alvarez-Díaz, Silvia, Becker, Karl-Friedrich, Gamallo, Carlos, de Herreros, Antonio García, González-Sancho, José Manuel, Muñoz, Alberto
• Format: Journal Article
• Language: English
• Published: England 01.03.2007
• Subjects: Animals; beta Catenin - genetics; beta Catenin - metabolism; Calcitriol - analogs & derivatives; Calcitriol - pharmacology; Cell Line, Tumor; Cell Movement - drug effects; Cell Proliferation - drug effects; Colonic Neoplasms - metabolism; Female; Humans; Mice; Mice, SCID; Microfilament Proteins - metabolism; Neoplasm Transplantation; Neuropeptides - metabolism; Nuclear Proteins - metabolism; Receptors, Calcitriol - metabolism; Signal Transduction; Snail Family Transcription Factors; Transcription Factors - genetics; Transcription Factors - metabolism; Vitamin D - analogs & derivatives; Vitamin D - pharmacology; Wnt Proteins - metabolism

The Wnt/beta-catenin signalling pathway is activated in 90% of human colon cancers by nuclear accumulation of beta-catenin protein due to its own mutation or to that of adenomatous polyposis coli. In the nucleus, beta-catenin regulates gene expression promoting cell proliferation, migration and inva...