The pattern of pegylated interferon-alpha2b and ribavirin treatment failure in cirrhotic patients depends on hepatitis C virus genotype

• Published in: Antiviral therapy Vol. 14; no. 4; p. 577
• Main Authors: Aghemo, Alessio, Rumi, Maria Grazia, Monico, Sara, Prati, Gian Maria, D'Ambrosio, Roberta, Donato, Maria Francesca, Colombo, Massimo
• Format: Journal Article
• Language: English
• Published: England 2009
• Subjects: Antiviral Agents - therapeutic use; Drug Therapy, Combination; Female; Genotype; Hepacivirus - genetics; Hepatitis C, Chronic - drug therapy; Humans; Interferon-alpha - administration & dosage; Liver Cirrhosis - drug therapy; Liver Cirrhosis - virology; Male; Middle Aged; Polyethylene Glycols - administration & dosage; Recombinant Proteins; Ribavirin - administration & dosage; RNA, Viral - blood; Treatment Failure

Failure of anti-hepatitis C therapy encompasses both primary non-response and post-treatment relapse. Treatment failure to pegylated interferon (PEG-IFN)-alpha2b and ribavirin (RBV) largely depends upon virus genotype, but the interaction between genotype, cirrhosis and pattern of treatment failure...