Alzheimer beta amyloid deposition enhanced by apoE epsilon4 gene precedes neurofibrillary pathology in the frontal association cortex of nondemented senior subjects - Yamaguchi, H; Sugihara, S; Ogawa, A; Oshima, N; Ihara, Y (Journal of neuropathology and experimental neurology, 2001)
Keywords: Adult; Aged; Aged, 80 and over; Aging - metabolism; Aging - pathology; Alleles; Alzheimer Disease - genetics; Alzheimer Disease - metabolism; Amyloid beta-Peptides - metabolism; Apolipoprotein E4; Apolipoproteins E - genetics; Association; Cytoplasmic Granules - pathology; Disease Progression; Frontal Lobe - metabolism; Frontal Lobe - pathology; Genotype; Humans; Immunoenzyme Techniques; Immunohistochemistry; Middle Aged; Neurofibrillary Tangles - pathology; Neuroglia - pathology; Peptide Fragments - metabolism; Risk Factors