Expression of neurexin Ialpha splice variants in sympathetic neurons: selective changes during differentiation and in response to neurotrophins

• Published in: Molecular and cellular neuroscience Vol. 15; no. 6; pp. 561 - 572
• Main Authors: Patzke, H, Ernsberger, U
• Format: Journal Article
• Language: English
• Published: United States 01.06.2000
• Subjects: Alternative Splicing - physiology; Animals; Brain-Derived Neurotrophic Factor - pharmacology; Cell Differentiation - drug effects; Cell Differentiation - genetics; Cells, Cultured; Chick Embryo; Cloning, Molecular; Ganglia, Sympathetic - cytology; Ganglia, Sympathetic - embryology; Ganglia, Sympathetic - physiology; Gene Expression Regulation, Developmental - drug effects; Glycoproteins; In Situ Hybridization; Molecular Sequence Data; Nerve Growth Factor - pharmacology; Nerve Tissue Proteins - genetics; Neuropeptides; Neurotrophin 3 - pharmacology; RNA, Messenger - analysis; Sequence Homology, Amino Acid

Neurexins are a surprisingly diverse group of alternatively spliced proteins possibly involved in neural cell recognition processes. We find neurexin Ialpha and its splice variants highly conserved between mammals and birds. In vivo, neurexin Ialpha is expressed in sympathetic neurons during target...