A new oncogenetic service of counseling and diagnosing for hereditary non-polyposis colorectal cancer (HNPCC)

• Published in: הרפואה Vol. 146; no. 7; p. 510
• Main Authors: Goldberg, Yael, Porat, Rinnat, Sagi, Michal, Eilat, Avital, Kedar, Inbal, Shochat, Chen, Mendelson, Suzan, Hamburger, Tamar, Nissan, Aviram, Hubert, Ayala, Shalev, Stavit, Bercovich, Dani, Pikarski, Eli, Lerer, Israela, Abeliovich, Dvorah, Pretetz, Tamar
• Format: Journal Article
• Language: Hebrew
• Published: Israel 01.07.2007
• Subjects: Adaptor Proteins, Signal Transducing - genetics; Base Pair Mismatch; Chromatography, High Pressure Liquid; Colorectal Neoplasms, Hereditary Nonpolyposis - diagnosis; Colorectal Neoplasms, Hereditary Nonpolyposis - epidemiology; Colorectal Neoplasms, Hereditary Nonpolyposis - genetics; Female; Genetic Counseling; Hospital Units; Humans; Male; MutL Protein Homolog 1; MutS Homolog 2 Protein - genetics; Nuclear Proteins - genetics; Probability

Hereditary non-polyposis colorectal cancer (HNPCC) is an autosomal dominant cancer predisposition syndrome associated with a high risk for colorectal cancer (up to 80%), endometrial cancer (up to 60%), and increased risk for other malignancies, mostly ovarian and urinary system tumors. HNPCC is caus...