Suppression of matrix metalloproteinase-9 by prostaglandin E(2) in peritoneal macrophage is associated with severity of endometriosis

• Published in: The American journal of pathology Vol. 167; no. 4; p. 1061
• Main Authors: Wu, Meng-Hsing, Shoji, Yutaka, Wu, Meng-Chi, Chuang, Pei-Chin, Lin, Chen-Chung, Huang, Mei-Feng, Tsai, Shaw-Jenq
• Format: Journal Article
• Language: English
• Published: United States 01.10.2005
• Subjects: Ascitic Fluid - chemistry; Blotting, Western; Case-Control Studies; Cells, Cultured; Dinoprostone - metabolism; Dinoprostone - pharmacology; Endometriosis - enzymology; Endometriosis - pathology; Female; Gene Expression Regulation, Enzymologic - drug effects; Humans; Interferon-gamma - pharmacology; Interleukin-1 - pharmacology; Macrophages, Peritoneal - enzymology; Matrix Metalloproteinase 9 - genetics; Matrix Metalloproteinase 9 - metabolism; Matrix Metalloproteinase Inhibitors; Models, Biological; Reverse Transcriptase Polymerase Chain Reaction; Severity of Illness Index

Decreased phagocytotic ability of macrophages has been reported to be associated with the severity of endometriosis, although the underlying mechanism remains uncharacterized. Expression and secretion of matrix metalloproteinase (MMP)-9 by macrophages is a means to degrade the extracellular matrix o...