Gammadelta receptor bearing T cells in scleroderma: enhanced interaction with vascular endothelial cells in vitro

• Published in: Clinical immunology (Orlando, Fla.) Vol. 91; no. 2; p. 188
• Main Authors: Kahaleh, M B, Fan, P S, Otsuka, T
• Format: Journal Article
• Language: English
• Published: United States 01.05.1999
• Subjects: Cell Division; Cells, Cultured; Cytotoxicity, Immunologic; Endothelium, Vascular - cytology; Granzymes; Humans; Receptors, Antigen, T-Cell, gamma-delta - immunology; RNA, Messenger; Scleroderma, Systemic - immunology; Serine Endopeptidases - genetics; T-Lymphocytes - immunology

In view of the documented perivascular mononuclear cell infiltration in the involved organs in scleroderma (SSc) and the reported accumulation of gammadelta-T cells in SSc skin and lung, we evaluated gammadelta-T cell interaction with endothelial cells (EC) in vitro. gammadelta- and alphabeta-T cell...