Activation of serum response element by D2 dopamine receptor is governed by Gbetagamma-mediated MAPK and Rho pathways and regulated by RGS proteins

• Published in: Pharmacology Vol. 79; no. 2; pp. 114 - 121
• Main Authors: Ho, Guyu, Wang, Yuren, Jones, Philip G, Young, Kathleen H
• Format: Journal Article
• Language: English
• Published: Switzerland 2007
• Subjects: Animals; beta-Adrenergic Receptor Kinases - metabolism; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Genes, Reporter; GTP-Binding Protein alpha Subunits - physiology; GTP-Binding Protein beta Subunits - physiology; GTP-Binding Protein gamma Subunits - physiology; Heterotrimeric GTP-Binding Proteins - physiology; Mitogen-Activated Protein Kinases - physiology; Pertussis Toxin - pharmacology; Quinpirole - pharmacology; Receptors, Dopamine D2 - agonists; Receptors, Dopamine D2 - physiology; RGS Proteins - physiology; rho GTP-Binding Proteins - physiology; Serum Response Element; Signal Transduction

In this study, we investigated the activation of the serum response element (SRE) by the D2 dopamine receptor (D2R) agonist quinpirole. Stimulation of CHO cells expressing the D2R by quinpirol evoked a dose-dependent SRE activation, which was completely blocked by overnight treatment of pertussis to...