ApoE promotes the proteolytic degradation of Abeta

• Published in: Neuron (Cambridge, Mass.) Vol. 58; no. 5; p. 681
• Main Authors: Jiang, Qingguang, Lee, C Y Daniel, Mandrekar, Shweta, Wilkinson, Brandy, Cramer, Paige, Zelcer, Noam, Mann, Karen, Lamb, Bruce, Willson, Timothy M, Collins, Jon L, Richardson, Jill C, Smith, Jonathan D, Comery, Thomas A, Riddell, David, Holtzman, David M, Tontonoz, Peter, Landreth, Gary E
• Format: Journal Article
• Language: English
• Published: United States 12.06.2008
• Subjects: Aging; Alzheimer Disease - drug therapy; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Amyloid beta-Peptides - metabolism; Animals; Animals, Newborn; Apolipoproteins E - pharmacology; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters - genetics; Behavior, Animal - drug effects; Benzoates - pharmacology; Benzylamines - pharmacology; Brain - pathology; Cells, Cultured; Disease Models, Animal; DNA-Binding Proteins - metabolism; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay - methods; Liver X Receptors; Memory - drug effects; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia - drug effects; Microglia - metabolism; Orphan Nuclear Receptors; Peptide Fragments - metabolism; Plaque, Amyloid - drug effects; Receptors, Cytoplasmic and Nuclear - metabolism; Time Factors

Apolipoprotein E is associated with age-related risk for Alzheimer's disease and plays critical roles in Abeta homeostasis. We report that ApoE plays a role in facilitating the proteolytic clearance of soluble Abeta from the brain. The endolytic degradation of Abeta peptides within microglia by...