Saturated, but not unsaturated, fatty acids induce apoptosis of human coronary artery endothelial cells via nuclear factor-kappaB activation

• Published in: Diabetes (New York, N.Y.) Vol. 55; no. 11; pp. 3121 - 3126
• Main Authors: Staiger, Katrin, Staiger, Harald, Weigert, Cora, Haas, Carina, Häring, Hans-Ulrich, Kellerer, Monika
• Format: Journal Article
• Language: English
• Published: United States 01.11.2006
• Subjects: Apoptosis - drug effects; Cell Cycle - drug effects; Coronary Vessels; Cycloheximide - pharmacology; Dactinomycin - pharmacology; Endothelium, Vascular - cytology; Endothelium, Vascular - drug effects; Endothelium, Vascular - physiology; Fatty Acids, Nonesterified - pharmacology; Fatty Acids, Unsaturated - pharmacology; Kinetics; NF-kappa B - metabolism

High nonesterified fatty acid (NEFA) concentrations, as observed in the metabolic syndrome, trigger apoptosis of human umbilical vein endothelial cells. Since endothelial apoptosis may contribute to atherothrombosis, we studied the apoptotic susceptibility of human coronary artery endothelial cells...