Planar polarity is positively regulated by casein kinase Iepsilon in Drosophila

• Published in: Current biology Vol. 16; no. 13; pp. 1329 - 1336
• Main Authors: Strutt, Helen, Price, Mary Ann, Strutt, David
• Format: Journal Article
• Language: English
• Published: England 11.07.2006
• Subjects: Adaptor Proteins, Signal Transducing - metabolism; Alleles; Animals; Body Patterning - genetics; Casein Kinase Ialpha - physiology; Casein Kinase Iepsilon - genetics; Casein Kinase Iepsilon - metabolism; Casein Kinase Iepsilon - physiology; Dishevelled Proteins; Drosophila - enzymology; Drosophila - genetics; Drosophila - growth & development; Drosophila Proteins - genetics; Drosophila Proteins - metabolism; Drosophila Proteins - physiology; Frizzled Receptors - metabolism; Mutation; Phenotype; Phosphoproteins - metabolism; Phosphorylation; Proto-Oncogene Proteins - metabolism; Receptors, G-Protein-Coupled - metabolism; Signal Transduction; Wings, Animal - anatomy & histology; Wings, Animal - metabolism; Wnt1 Protein

Members of the casein kinase I (CKI) family have been implicated in regulating canonical Wnt/Wingless (Wg) signaling by phosphorylating multiple pathway components. Overexpression of CKI in vertebrate embryos activates Wg signaling, and one target is thought to be the cytoplasmic effector Dishevelle...