In vitro development of rifampicin resistance in the epithelial cells

• Published in: Problemy tuberkuleza i bolezneĭ legkikh no. 8; p. 58
• Main Authors: Erokhina, M V, Aleksandrova, E A
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2006
• Subjects: Antitubercular Agents - pharmacology; Antitubercular Agents - therapeutic use; Humans; In Vitro Techniques; Respiratory Mucosa - drug effects; Respiratory Mucosa - pathology; Rifampin - pharmacology; Rifampin - therapeutic use; Tuberculosis, Multidrug-Resistant; Tuberculosis, Pulmonary - drug therapy; Tuberculosis, Pulmonary - pathology

It has been first in vitro demonstrated on a model of epithelial cells that rifampicin may develop not only at the level of Mycobacterium tuberculosis, but also at the level of somatic cells. The mechanism of this phenomenon, its specificity (whether cross resistance to other antituberculous agents...