The evaluation of noninvasive samples for detecting anti-cytomegalovirus IgG antibodies

Patients admitted in dialysis centers are at greatest risk to achieve blood-borne infections. One of the most frequent is the cytomegalovirus infection, acquired from transfused blood products. The aim of our study was to determine the prevalence of IgG anti-CMV in patients on dialysis at the "...

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Bibliographic Details
Published inRevista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi Vol. 103; no. 3-4; p. 136
Main Authors Bosnea, D, Apetrei, C, Covic, A, Covic, M
Format Journal Article
LanguageRomanian
Published Romania 01.07.1999
Subjects
Adult
Antibodies, Viral - analysis
Capillaries
Cytomegalovirus - immunology
Enzyme-Linked Immunosorbent Assay - methods
Humans
Immunoglobulin G - analysis
Renal Dialysis
Saliva - immunology
Sensitivity and Specificity
Veins
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Summary:Patients admitted in dialysis centers are at greatest risk to achieve blood-borne infections. One of the most frequent is the cytomegalovirus infection, acquired from transfused blood products. The aim of our study was to determine the prevalence of IgG anti-CMV in patients on dialysis at the "C. I. Parhon" Hospital from Iaşi (Romania). In addition, the role of non-invasive samples (saliva and capillary blood) for such epidemiological studies was determined. ELISA Wellcome anti-CMV IgG was used for identification of specific antibodies in serum, capillary blood, saliva. The prevalence of anti-CMV IgG in the group of study was higher than that established in general populations and 79.06% saliva specimens and 93.76% of capillary blood samples were positive. To establish the specificity, sensitivity and predictive values of Wellcome anti-CMV when non-invasive samples are used, we compared the results obtained by testing saliva and capillary blood to those obtained by testing serum. We may conclude that the non-invasive samples are useful for CMV-infection surveillance in risk groups.
ISSN:0048-7848