Transforming growth factor beta1 and additional renoprotective effect of combination ACE inhibitor and angiotensin II receptor blocker in hypertensive subjects with minor renal abnormalities: a 24-week randomized controlled trial

• Published in: Journal of hypertension Vol. 23; no. 3; p. 657
• Main Authors: Scaglione, Rosario, Argano, Christiano, Corrao, Salvatore, Di Chiara, Tiziana, Licata, Anna, Licata, Giuseppe
• Format: Journal Article
• Language: English
• Published: England 01.03.2005
• Subjects: Angiotensin II Type 1 Receptor Blockers - administration & dosage; Angiotensin-Converting Enzyme Inhibitors - administration & dosage; Biomarkers; Drug Therapy, Combination; Female; Humans; Hypertension, Renal - drug therapy; Hypertension, Renal - metabolism; Kidney - drug effects; Kidney - physiology; Losartan - administration & dosage; Male; Middle Aged; Ramipril - administration & dosage; Renal Insufficiency - complications; Severity of Illness Index; Transforming Growth Factor beta - metabolism; Transforming Growth Factor beta1

To verify the benefit of renin-angiotensin system blockade in hypertension, the effects of 24 weeks' losartan and ramipril treatment, both alone and in combination, on urinary albumin excretion (UAE) and circulating transforming growth factor beta1 (TGF beta1) have been evaluated in hypertensiv...