Changes of the activity and expression of gamma-glutamylcysteine synthetase in patients with chronic obstructive pulmonary disease

• Published in: Zhonghua jiehe he huxi zazhi Vol. 28; no. 2; p. 97
• Main Authors: Lin, Shu-dian, Dai, Ai-guo, Xu, Ping
• Format: Journal Article
• Language: Chinese
• Published: China 01.02.2005
• Subjects: Female; Glutamate-Cysteine Ligase - genetics; Glutamate-Cysteine Ligase - metabolism; Glutathione - blood; Humans; Immunohistochemistry; In Situ Hybridization; Lung - enzymology; Male; Middle Aged; Pulmonary Disease, Chronic Obstructive - enzymology; Reactive Oxygen Species - blood; Respiratory Function Tests; RNA, Messenger - biosynthesis

To investigate the oxidative/antioxidative status in patients with chronic obstructive pulmonary disease (COPD), and to study the expression and location of gamma-glutamylcysteine synthetase (gamma-GCS) in lung tissues. (1) Serum samples of 13 patients with COPD in exacerbation and 9 healthy non-smo...