Modeling of differentiation and physiological involution in the tissues of induced cancer of the mammary gland

• Published in: Voprosy onkologij Vol. 34; no. 10; p. 1224
• Main Authors: Khaetskiĭ, I K, Nikitchenko, V V, Andrushchak, L I, Khaetskaia, V I, Pinchuk, V G
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 1988
• Subjects: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Differentiation; Cell Survival; Estrogens - administration & dosage; Mammary Glands, Animal - pathology; Mammary Neoplasms, Experimental - chemically induced; Mammary Neoplasms, Experimental - drug therapy; Mammary Neoplasms, Experimental - pathology; Papaverine - administration & dosage; Rats; Tamoxifen - administration & dosage; Vitamin A - administration & dosage

The experiments used rats with mammary tumors induced by intravenous injection of DMBA. The animals were treated with alternating courses of estrogen and anti-estrogen (tamoxifen). The former was given in combination with papaverin and low doses of vitamin A. This was followed by light and electron...