Decreased beta 2-adrenoceptor density and decreased isoproterenol induced c-AMP increase in juvenile type I diabetes mellitus: an additional cause of severe hypoglycaemia in childhood diabetes?

• Published in: European journal of pediatrics Vol. 152; no. 10; p. 797
• Main Authors: Schwab, K O, Bartels, H, Martin, C, Leichtenschlag, E M
• Format: Journal Article
• Language: English
• Published: Germany 01.10.1993
• Subjects: Adolescent; Adult; Child; Child, Preschool; Cyclic AMP - metabolism; Diabetes Mellitus, Type 1 - classification; Diabetes Mellitus, Type 1 - complications; Diabetes Mellitus, Type 1 - metabolism; Granulocytes - metabolism; Humans; Hypoglycemia - complications; Hypoglycemia - physiopathology; In Vitro Techniques; Iodocyanopindolol; Isoproterenol - pharmacology; Lymphocytes - metabolism; Pindolol - analogs & derivatives; Pindolol - metabolism; Receptors, Adrenergic, beta - analysis

Little is known about the receptor and post receptor mechanisms of sympathoadrenal signal transmission in type I diabetes mellitus. Therefore, we examined the maximum binding of granulocyte beta 2-adrenoceptors and the in vitro c-AMP accumulation in lymphocytes of 24 children and adolescents with di...