Lipid-mobilizing activity of a synthetic peptide identical to 33-44 fragment of human growth hormone

The lipid-mobilizing activity of a synthetic peptide, NH2-Phe-Glu-Glu-Ala-Tyr-Ile-Pro-Lys-Glu-Gln-Lys-Tyr-Ser-Phe-COOH, corresponding to the 31-44 amino-acid sequence of human growth hormone, was studied. The peptide stimulated lypolysis upon administration to fasted rats and during incubation with...

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Bibliographic Details
Published inBiokhimiia (Moscow, Russia) Vol. 41; no. 5; p. 843
Main Authors Iudaev, N A, Pankov, Iu A, Keda, Iu M, Shvachkin, Iu P, Riabtsev, M N
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.05.1976
Subjects
Adipose Tissue - metabolism
Animals
Dose-Response Relationship, Drug
Fatty Acids, Nonesterified - blood
Growth Hormone - pharmacology
In Vitro Techniques
Lipid Mobilization - drug effects
Peptides - administration & dosage
Peptides - isolation & purification
Peptides - pharmacology
Rabbits
Rats
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Summary:The lipid-mobilizing activity of a synthetic peptide, NH2-Phe-Glu-Glu-Ala-Tyr-Ile-Pro-Lys-Glu-Gln-Lys-Tyr-Ser-Phe-COOH, corresponding to the 31-44 amino-acid sequence of human growth hormone, was studied. The peptide stimulated lypolysis upon administration to fasted rats and during incubation with isolated epidiymal adiposed tissue of rat and perirenal adiposed tissue of rabbit. The lipid-mobilizing effect of the peptide,unlike the corresponding effect of the native growth hormone, developed fast and was markedly pronounced 15-30 min after the incubation was started. Direct dependence between the peptide dose logarithm and the effect studied was observed at concentrations of 0.01-10microng/ml during incubation with rat adipose tissue and at 0.001-0.1 microng/ml during incubation with rabbit tissue.
ISSN:0320-9725