Clara cell protein (CC-16) induces a phospholipase A2-mediated inhibition of fibroblast migration in vitro

• Published in: American journal of respiratory and critical care medicine Vol. 152; no. 1; p. 290
• Main Authors: Lesur, O, Bernard, A, Arsalane, K, Lauwerys, R, Bégin, R, Cantin, A, Lane, D
• Format: Journal Article
• Language: English
• Published: United States 01.07.1995
• Subjects: Adult; Bleomycin - adverse effects; Bronchoalveolar Lavage Fluid - chemistry; Cell Division; Chemotaxis; Female; Fibroblasts - cytology; Fibroblasts - physiology; Humans; Immunohistochemistry; Lung - drug effects; Lung - metabolism; Lung - pathology; Male; Middle Aged; Phospholipases - antagonists & inhibitors; Phospholipases A - antagonists & inhibitors; Phospholipases A - metabolism; Phospholipases A - physiology; Phospholipases A2; Proteins - pharmacology; Proteins - physiology; Pulmonary Fibrosis - chemically induced; Pulmonary Fibrosis - metabolism; Pulmonary Fibrosis - pathology; Uteroglobin

Clara cell protein (CC-16, also designated CC-10) is synthesized by the bronchiolar epithelium and has been suggested as an inhibitor of phospholipase A2 (PLA2) activity. Therefore, CC-16 is a candidate for controlling inflammatory events in the lung. Because CC-16 amounts and function may be altere...