Extracellular ATP causes of loss of L-selectin from human lymphocytes via occupancy of P2Z purinocepters

• Published in: Journal of cellular physiology Vol. 166; no. 3; p. 637
• Main Authors: Jamieson, G P, Snook, M B, Thurlow, P J, Wiley, J S
• Format: Journal Article
• Language: English
• Published: United States 01.03.1996
• Subjects: Adenosine Triphosphate - analogs & derivatives; Adenosine Triphosphate - metabolism; Adenosine Triphosphate - pharmacology; Alkaloids - pharmacology; Calcium - physiology; Cells, Cultured; Down-Regulation - drug effects; Humans; L-Selectin - metabolism; Leukemia, Lymphocytic, Chronic, B-Cell - metabolism; Lymphocytes - metabolism; Magnesium - pharmacology; Protein Kinase C - physiology; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2 - metabolism; Staurosporine; Tetradecanoylphorbol Acetate - pharmacology; Tumor Cells, Cultured
• ISSN: 0021-9541
• DOI: 10.1002/(SICI)1097-4652(199603)166:3<637::AID-JCP19>3.0.CO;2-3

Lymphocytes from normal subjects or patients with chronic lymphocytic leukemia are known to possess receptors for extracellular ATP termed P2Z purinoceptors whose physiological role is undefined. Addition of extracellular ATP (50-500 microM) to both normal and leukemic lymphocytes caused loss of bin...