Certain biochemical features of leukocytes in blast crisis of chronic myelogenous leukemia

The content of nuclear high mobility group (HMG) proteins, activities of ornithine decarboxylase (ODC), adenosine deaminase (ADA) and purine nucleoside phosphorylase (PNP) and also glycosaminoglycan (GAG) content and composition were studied in leukocytes of patients with chronic myelogenous leukemi...

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Bibliographic Details
Published inVoprosy meditsinskoi khimii Vol. 44; no. 3; p. 274
Main Authors Kharchenko, M F, Rybakova, L P, Filanovskaia, L I, Saltykova, L B, Bitiukova, E S, Shcherbakova, E G, Rukavitsyn, O A, Bessmel'tsev, S S, Abdulkadyrov, K M, Blinov, M M
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.05.1998
Subjects
Blast Crisis - blood
Blast Crisis - enzymology
Glycosaminoglycans - blood
High Mobility Group Proteins - blood
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - blood
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - enzymology
Leukocytes - enzymology
Leukocytes - metabolism
Ornithine Decarboxylase - blood
Purine-Nucleoside Phosphorylase - blood
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Summary:The content of nuclear high mobility group (HMG) proteins, activities of ornithine decarboxylase (ODC), adenosine deaminase (ADA) and purine nucleoside phosphorylase (PNP) and also glycosaminoglycan (GAG) content and composition were studied in leukocytes of patients with chronic myelogenous leukemia in the phase of blast crisis (BC CML). Myeloid and lymphoid cytochemical variants of BC CML differ by biochemical parameters. It is suggested, that the content of HMG-proteins, activities of ODC and PNP, and electrophoretic patterns of GAGs could be used in diagnostics of two main variants of BC CML.
ISSN:0042-8809