Gastrin13 and the C-terminal octapeptide of cholecystokinin are differently coupled to G-proteins in guinea-pig brain membranes

• Published in: European journal of pharmacology Vol. 267; no. 3; pp. 297 - 305
• Main Authors: Lallement, J C, Galleyrand, J C, Lima-Leite, A C, Fulcrand, P, Martinez, J
• Format: Journal Article
• Language: English
• Published: Netherlands 17.05.1994
• Subjects: Animals; Benzodiazepinones - metabolism; Binding Sites; Brain - metabolism; Devazepide; Gastrins - chemistry; Gastrins - metabolism; GTP-Binding Proteins - metabolism; Guanosine 5'-O-(3-Thiotriphosphate) - pharmacology; Guinea Pigs; In Vitro Techniques; Male; Peptide Fragments - metabolism; Phenylurea Compounds; Sincalide - metabolism

In the course of our study concerning gastrin and cholecystokinin (CCK) receptors, we synthesized and characterized a labelled gastrin ligand, [125I]BH[Leu15]gastrin-(5-17) (3-(3-[125I]iodo-4-hydroxyphenyl)propionyl[Leu15]gastrin-(5-17)). On isolated canine fundic mucosal cells and human Jurkat lymp...