Localization of the immunodominant site in the hepatitis B virus core antigen using synthetic peptides

• Published in: Bioorganicheskaia khimiia Vol. 20; no. 11; p. 1175
• Main Authors: Semiletov, Iu A, Karpova, V A, Kalinina, T I, Khudiakov, Iu E
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01.11.1994
• Subjects: Amino Acid Sequence; Enzyme-Linked Immunosorbent Assay; Hepatitis B Antibodies - immunology; Hepatitis B Core Antigens - chemistry; Hepatitis B Core Antigens - immunology; Humans; Immunodominant Epitopes - analysis; Immunodominant Epitopes - immunology; Molecular Sequence Data; Peptides - chemistry; Protein Structure, Secondary; Serum Albumin, Bovine - chemistry

Based on theoretical analysis of secondary structure and hydrophilicity data, the region (residues 73-89) of the HBV core-antigen presumably containing the antigenic determinant has been revealed. The epitope mapping of this region with the use of synthetic peptides, obtained by the pin technology a...