Effect of spatial coupling of amino acid residues on the possibility of mutational substitution in globular proteins

• Published in: Molekuliarnaia biologiia Vol. 20; no. 5; p. 1192
• Main Authors: Lukashev, V A, Bachinskiĭ, A G, Kulichkov, V A
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01.09.1986
• Subjects: Amino Acid Sequence; Mutation; Protein Conformation; Proteins - analysis; Proteins - genetics

Amino acid residues can be divided into similar groups by frequencies of interreplacements in the evolutionary pathway and by trends to spatial contacts at the tertiary structures of globular proteins. Each residue was compared to the cluster of spatial surrounding--the totality of residues spaciall...