Comparative cytophotometric and cytomorphometric studies of concave cells and atypical squamous epithelial cells of the cervix uteri

• Published in: Zentralblatt fur allgemeine Pathologie u. pathologische Anatomie Vol. 131; no. 6; p. 517
• Main Authors: Beust, M, Barten, M, Kreuzberg, M, Krygier-Stojałowska, A, Rohde, E
• Format: Journal Article
• Language: German
• Published: Germany 1986
• Subjects: Cell Nucleus - analysis; Cell Nucleus - ultrastructure; Cervix Uteri - pathology; Cytophotometry; DNA - analysis; Epithelium - pathology; Female; Humans; Papillomaviridae; Tumor Virus Infections - complications; Tumor Virus Infections - pathology; Uterine Cervical Diseases - complications; Uterine Cervical Diseases - pathology; Uterine Cervical Neoplasms - complications; Uterine Cervical Neoplasms - pathology
• ISSN: 0044-4030

Cytologic slides from 11 women with clinical, cytological and histological signs of a papillomavirus infection of the cervix uteri are investigated by cytophotometry and cytomorphometry. The mean values of DNA content, chromatin density, nuclear area and nuclear circumference of koilocytes were notably higher than for atypical or normal squamous cells. In those patients with concurrent cervical intraepithelial neoplasia the DNA content of koilocytes was inversely related to the degree of atypia. Squamous cells with HPV-induced lesions can be characterized by cytophotometry and cytomorphometry as a distinct cell population forming a continuum with the preneoplastic epithelium.