Comparative cytophotometric and cytomorphometric studies of concave cells and atypical squamous epithelial cells of the cervix uteri

Cytologic slides from 11 women with clinical, cytological and histological signs of a papillomavirus infection of the cervix uteri are investigated by cytophotometry and cytomorphometry. The mean values of DNA content, chromatin density, nuclear area and nuclear circumference of koilocytes were nota...

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Published inZentralblatt fur allgemeine Pathologie u. pathologische Anatomie Vol. 131; no. 6; p. 517
Main Authors Beust, M, Barten, M, Kreuzberg, M, Krygier-Stojałowska, A, Rohde, E
Format Journal Article
LanguageGerman
Published Germany 1986
Subjects
Cell Nucleus - analysis
Cell Nucleus - ultrastructure
Cervix Uteri - pathology
Cytophotometry
DNA - analysis
Epithelium - pathology
Female
Humans
Papillomaviridae
Tumor Virus Infections - complications
Tumor Virus Infections - pathology
Uterine Cervical Diseases - complications
Uterine Cervical Diseases - pathology
Uterine Cervical Neoplasms - complications
Uterine Cervical Neoplasms - pathology
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Summary:Cytologic slides from 11 women with clinical, cytological and histological signs of a papillomavirus infection of the cervix uteri are investigated by cytophotometry and cytomorphometry. The mean values of DNA content, chromatin density, nuclear area and nuclear circumference of koilocytes were notably higher than for atypical or normal squamous cells. In those patients with concurrent cervical intraepithelial neoplasia the DNA content of koilocytes was inversely related to the degree of atypia. Squamous cells with HPV-induced lesions can be characterized by cytophotometry and cytomorphometry as a distinct cell population forming a continuum with the preneoplastic epithelium.
ISSN:0044-4030