Endoscopic diagnosis of colonic tuberculosis

• Published in: Deutsche medizinische Wochenschrift Vol. 119; no. 48; p. 1653
• Main Authors: Wedmann, B, Wegener, M, Adamek, R J, Müller, K M
• Format: Journal Article
• Language: German
• Published: Germany 02.12.1994
• Subjects: Aged; Cecum - pathology; Colon - pathology; Colonic Diseases - diagnosis; Colonic Diseases - drug therapy; Colonoscopy; Drug Therapy, Combination; Female; Humans; Isoniazid - therapeutic use; Mycobacterium tuberculosis - isolation & purification; Pyrazinamide - therapeutic use; Rifampin - therapeutic use; Tuberculosis, Gastrointestinal - diagnosis; Tuberculosis, Gastrointestinal - drug therapy
• ISSN: 0012-0472

A 67-year-old woman had developed weakness, fatigue and a 10 kg weight loss over the past year. On examination a cylindrical mass was palpated in the right middle abdominal cavity. Erythrocyte sedimentation rate was increased to 87/126 mm, there was an hypochromic anaemia (haemoglobin 9.1 mg/dl) and an hypoalbuminaemia (32 g/l) with an increase in alpha 2-globulins (9.4 g/l), Cholinesterase activity was decreased to 588 U/l. X-ray film of the abdomen revealed a calcified mesenteric lymph-node and coloscopy demonstrated polypoid tumorous changes with ulcerations, extending from the pole of the caecum to the right flexure. Histological examination showed epithelioid-cell granulomas with Langhans giant cells. Culture grew Mycobacterium tuberculosis, confirming the diagnosis of intestinal tuberculosis. She was treated with oral doses of isoniazid (300 mg daily), rifampicin (600 mg daily) and pyrazinamide (2 g daily) for 2 months, followed by isoniazid and rifampicin for a further 4 months. After this the laboratory tests were within normal limits and urine as well as stool samples contained no acid-fast bacilli. As the patient felt so well she declined another coloscopy.