Suppression of the adhesive properties of mucosal microflora by ampicillin in peptic ulcer

Persistence of mucous bacteria in the mucosa of the stomach and duodenum was studied bacteriologically and electron microscopically in 132 patients with peptic ulcer. 235 microbial strains were isolated from the mucosa and its surface in 96 per cent of the patients. 80.8 per cent of the isolates bel...

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Bibliographic Details
Published inAntibiotiki Vol. 29; no. 2; p. 127
Main Author Sytnik, S I
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.02.1984
Subjects
Adhesiveness
Ampicillin - pharmacology
Duodenum - microbiology
Duodenum - ultrastructure
Gastric Mucosa - microbiology
Gastric Mucosa - ultrastructure
Humans
Intestinal Mucosa - microbiology
Intestinal Mucosa - ultrastructure
Microscopy, Electron
Peptic Ulcer - microbiology
Staphylococcus - drug effects
Streptococcus - drug effects
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Summary:Persistence of mucous bacteria in the mucosa of the stomach and duodenum was studied bacteriologically and electron microscopically in 132 patients with peptic ulcer. 235 microbial strains were isolated from the mucosa and its surface in 96 per cent of the patients. 80.8 per cent of the isolates belonged to different species of Staphylococcus and Streptococcus. The other 19.2 per cent of the isolates belonged to 9 rare bacterial species. 235 antibioticograms were analysed and it was shown that the predominating part of the isolates was mainly sensitive to ampicillin. Then follow ampiox, dicloxacillin and benzylpenicillin. Ampicillin was recommended for preoperative sanation of the stomach mucosa. 30 patients were given ampicillin orally in a dose of 0.25 g 4 times a day for 3 days before operations. It was found that the drug inhibited the adhesive properties of the mucous bacteria and even killed them.
ISSN:0003-5637