Mechanisms of potentiating and prolonging the radioprotective effect of multicomponent compounds

• Published in: Radiobiologiia Vol. 23; no. 3; p. 389
• Main Authors: Vladimirov, V G, Smirnova, S M, Tarnopol'skaia, L G
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01.05.1983
• Subjects: 5-Methoxytryptamine - metabolism; Animals; Cystamine - metabolism; Delayed-Action Preparations; Drug Combinations; Drug Synergism; Guanylthiourea - metabolism; Isothiuronium - analogs & derivatives; Isothiuronium - metabolism; Male; Mice; Radiation-Protective Agents - metabolism; Radiation-Protective Agents - pharmacology; Tissue Distribution

A study was made of the effect of mexamine, etiron and gutimine on the pattern of distribution of cystamine within the body and the rate of its conversion in tissues of albino mice. It was shown that the potentiation and prolongation of the radioprotective effect is based on the ability of the compl...