Combined-modality treatment of small-cell lung cancer: randomized comparison of three induction chemotherapies followed by maintenance chemotherapy with or without radiotherapy to the chest. Swiss Group for Clinical Cancer Research (SAKK)

• Published in: Annals of oncology Vol. 5; no. 10; p. 921
• Main Authors: Joss, R A, Alberto, P, Bleher, E A, Ludwig, C, Siegenthaler, P, Martinelli, G, Sauter, C, Schatzmann, E, Senn, H J
• Format: Journal Article
• Language: English
• Published: England 01.12.1994
• Subjects: Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Carcinoma, Small Cell - drug therapy; Carcinoma, Small Cell - radiotherapy; Carcinoma, Small Cell - therapy; Cisplatin - administration & dosage; Combined Modality Therapy; Contraindications; Cranial Irradiation; Cyclophosphamide - administration & dosage; Doxorubicin - administration & dosage; Etoposide - administration & dosage; Female; Follow-Up Studies; Humans; Lung Neoplasms - drug therapy; Lung Neoplasms - radiotherapy; Lung Neoplasms - therapy; Male; Methotrexate - administration & dosage; Middle Aged; Prospective Studies; Radiotherapy; Radiotherapy, Adjuvant; Regression Analysis; Remission Induction; Switzerland; Thorax; Vincristine - administration & dosage

From 1980 to 1983 the Swiss Group for Clinical Cancer Research (SAKK) performed a randomised phase III trial in patients with small-cell lung cancer with the objective of improving the results of induction chemotherapy and defining the role of consolidating chest irradiation. Patients were initially...