Endoscopic, histologic and morphometric evaluation of the gastric mucosa in patients with osteoarthritis treated with piroxicam and zinc acexamate

• Published in: Gastroenterología y hepatología Vol. 21; no. 5; p. 212
• Main Authors: Guilarte López-Mañas, J, Valenzuela Barranco, M, Caballero Plasencia, A M, Martín Ruiz, J L
• Format: Journal Article
• Language: Spanish
• Published: Spain 01.05.1998
• Subjects: Adult; Aged; Aminocaproates; Aminocaproic Acid - therapeutic use; Anti-Inflammatory Agents, Non-Steroidal - adverse effects; Anti-Ulcer Agents - therapeutic use; Double-Blind Method; Female; Gastric Mucosa - drug effects; Gastric Mucosa - pathology; Gastrointestinal Diseases - chemically induced; Gastrointestinal Diseases - pathology; Gastrointestinal Diseases - prevention & control; Gastroscopy; Humans; Male; Middle Aged; Osteoarthritis - drug therapy; Piroxicam - adverse effects

Zinc acexamate (ZAM) is an antiulcer agent with antisecretory and gastroprotective properties. The aim of this study was to evaluate endoscopically and morphometrically the efficacy of ZAM in the prophylaxis of gastroduodenal lesions induced by pyroxicam. Thirty nine patients from 30 to 70 years of...