Evaluation of the sialic acid content of LDL as a marker of coronary calcification and extracoronary atherosclerosis in asymptomatic hypercholesterolemic subjects. PCVMETRA Group

• Published in: Arteriosclerosis, thrombosis, and vascular biology Vol. 15; no. 3; p. 334
• Main Authors: Chappey, B, Myara, I, Giral, P, Kerharo, G, Plainfosse, M C, Levenson, J, Simon, A, Moatti, N
• Format: Journal Article
• Language: English
• Published: United States 01.03.1995
• Subjects: Adult; Aged; Arteriosclerosis - blood; Arteriosclerosis - complications; Arteriosclerosis - prevention & control; Biomarkers; Calcinosis - blood; Calcinosis - complications; Coronary Vessels; Female; Humans; Hypercholesterolemia - blood; Hypercholesterolemia - complications; Lipoproteins, LDL - blood; Lipoproteins, LDL - chemistry; Male; Middle Aged; N-Acetylneuraminic Acid; Sialic Acids - analysis; Tomography, X-Ray Computed - methods; Ultrasonography

Recent studies have shown that the sialic acid content of LDL isolated from patients with angiographically demonstrated advanced coronary atherosclerosis is lower than that of LDL isolated from healthy subjects. These observations raise the question as to whether LDL sialic acid content could be use...