Synthesis and study of cyclic and linear analogs of neurotensin

• Published in: Bioorganicheskaia khimiia Vol. 11; no. 12; p. 1589
• Main Authors: Grinshteĭne, I V, Myshliakova, N V, Vegner, R E, Vosekalna, I A, Gaĭlite, E A
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01.12.1985
• Subjects: Amino Acid Sequence; Animals; Blood Pressure - drug effects; Chromatography, High Pressure Liquid; Circular Dichroism; Guinea Pigs; Ileum - drug effects; In Vitro Techniques; Male; Muscle Contraction - drug effects; Muscle, Smooth - drug effects; Neurotensin - analogs & derivatives; Neurotensin - chemical synthesis; Neurotensin - pharmacology; Peptides, Cyclic - chemical synthesis; Peptides, Cyclic - pharmacology; Protein Conformation; Rats

New cyclic analogues of neurotensin (NT): [cyclo (13---8), Gly8]NT-(8-13), [cyclo (13---7), Gly7]NT-(7-13), [cyclo (13---5 epsilon), Lys5]NT-(5-13), [cyclo (13---4 epsilon), Lys4]NT-(4-13), and their linear precursors have been synthesized. The latter (protected linear compounds) were prepared by so...