Properties of polyreactive immunoglobulins

Some biological properties of polyreactive antibodies (PRABs) from the serum of mice, rabbit and cattle are investigated. Optimal parameters of the activation process are determined. It is shown that solution of KSCN (potassium rhodanide) more effectively impedes interaction of PRABs with the antige...

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Bibliographic Details
Published inUkrainskij biohimičeskij žurnal Vol. 65; no. 5; p. 21
Main Authors Bobrovnik, S A, Marinets, A V
Format Journal Article
LanguageRussian
Published Ukraine 01.09.1993
Subjects
Animals
Antibody Specificity
Antigen-Antibody Reactions
Cattle
Enzyme-Linked Immunosorbent Assay
Immunoglobulins - immunology
Mice
Rabbits
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Summary:Some biological properties of polyreactive antibodies (PRABs) from the serum of mice, rabbit and cattle are investigated. Optimal parameters of the activation process are determined. It is shown that solution of KSCN (potassium rhodanide) more effectively impedes interaction of PRABs with the antigen on the immunological plate than interaction between specific antibodies. Dynamics of binding of PRABs and affine-purified antibodies to an immobilized antigen is analyzed. The competitive ELISA shows the absence of specificity of PRABs and their less avidity in comparison with the usual antibodies. It is supposed that PRABs play an essential role in the immune system of animals and man.
ISSN:0201-8470