Biochemical and functional changes during immunization of rats with angiotensin II

Angiotensin-converting enzyme (ACE) activity in serum and some brain areas, level of angiotensin I in the blood and drinking behaviour during immunization of rats against conjugate of angiotensin II with bovine serum albumin (BSA) were studied. The results show that an increase in antibodies against...

Full description

Saved in:
Bibliographic Details
Published inBiulleten' eksperimental'noi biologii i meditsiny Vol. 108; no. 8; p. 181
Main Authors Komissarova, E V, Tolpygo, S M, Polyntsev, Iu V, Krizhevskaia, Iu V, Shestakov, P A, Kotov, A V, Gomazkov, O A
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.08.1989
Subjects
Angiotensin I - blood
Angiotensin II - immunology
Animals
Antibodies - analysis
Brain - enzymology
Drinking Behavior
Immunization
Male
Peptidyl-Dipeptidase A - analysis
Peptidyl-Dipeptidase A - blood
Rats
Rats, Inbred Strains
Serum Albumin, Bovine
Online AccessGet more information

Cover

More Information
Summary:Angiotensin-converting enzyme (ACE) activity in serum and some brain areas, level of angiotensin I in the blood and drinking behaviour during immunization of rats against conjugate of angiotensin II with bovine serum albumin (BSA) were studied. The results show that an increase in antibodies against angiotensin II was correlated with elevated ACE activity in serum. There was a distinct tendency towards elevated level of angiotensin I in the blood. After a 6 month's immunization ACE-activity was reduced twofold to threefold in midbrain and hypothalamus-thalamus. During immunization water-uptake was increased by 40-45%.
ISSN:0365-9615