Alpha 2-adrenoceptor mediated inhibition of [3H]dopamine release from nucleus accumbens slices and monoamine levels in a rat model for attention-deficit hyperactivity disorder

• Published in: Neurochemical research Vol. 20; no. 4; p. 427
• Main Authors: de Villiers, A S, Russell, V A, Sagvolden, T, Searson, A, Jaffer, A, Taljaard, J J
• Format: Journal Article
• Language: English
• Published: United States 01.04.1995
• Subjects: Adrenergic alpha-2 Receptor Agonists; Animals; Antihypertensive Agents - pharmacology; Attention Deficit Disorder with Hyperactivity - metabolism; Biogenic Monoamines - metabolism; Brimonidine Tartrate; Disease Models, Animal; Dopamine - metabolism; Hypertension - metabolism; In Vitro Techniques; Male; Neurons - metabolism; Norepinephrine - metabolism; Nucleus Accumbens - cytology; Nucleus Accumbens - metabolism; Quinoxalines - pharmacology; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Adrenergic, alpha-2 - physiology; Tritium

The spontaneously hypertensive rat (SHR) has been proposed as an animal model for attention-deficit hyperactivity disorder (ADHD). The behavioural problems have been suggested to be secondary to altered reinforcement mechanisms in which nucleus accumbens dopaminergic activity plays an important role...